Canada Research Chair
Ethnic Diversity & Cardiovascular Disease

Identifying the health behaviours and genetic aspects that contribute to the risk factors for cardiovascular disease in ethnic communities in Canada.

While obesity, diabetes and cardiovascular disease (CVD) affect everybody, research has shown that certain populations, such as South Asians and Aboriginal peoples, are at generally higher risk than those of Caucasian origin.

Dr. Sonia Anand, Canada Research Chair in Ethnic Diversity and Cardiovascular Disease, is identifying health behaviour risk factors in diverse ethnic groups. Anand is examining factors such as elevated blood glucose levels, dietary patterns and genetic factors to develop prevention strategies to reduce cardio-metabolic risk factors and CVD for those most in jeopardy. She is also examining these factors in diverse populations across the infant-child-adult life span.

Anand aims to identify adverse health behaviours and genetic factors that will shed light on the causes of CVD risk factors among high-risk groups. Identification of these behaviours and genetic factors could also improve the accuracy of risk prediction for diabetes and CVD and motivate behavioural changes. In addition, her approach could validate ethnic-specific measurement tools that will allow for comparisons across diverse ethnic populations.

Anand is also studying genetic molecular discoveries and data on dietary factors, such as energy intake and macronutrient composition. This information will offer excellent windows into how environmental and genetic measures affect the development of cardio-metabolic factors in high-risk groups.

Anand’s examination of high risk populations will provide greater insight into the causes and risk factors of CVD. Her research could eventually lead to the development of prevention strategies to stem the leading cause of premature deaths in ethnic populations.

Endowed Research Chair
Heart and Stroke Foundation / Michael G. DeGroote Chair in Population Health Research

Development of theoretical and computational methods for predicting reactions in complex chemical systems.

At its heart, chemistry is the study of how substances are transformed through chemical reactions. The traditional role of chemical theory has been to develop conceptual, mathematical and computational tools for describing how chemical reactions occur. Despite the many advances in chemistry over the years, the computational methods developed to predict the products and key intermediates of a chemical reaction are limited to small molecules, rapid reactions or systems in which no new chemical bonds are formed. Novel approaches are needed to address complex chemical systems such as biochemical reactions, catalysis, molecular electronics and nanomaterials.

In his early work as a graduate and postdoctoral researcher, Dr. Paul Ayers has made significant achievements in the field of density functional theory and electron structure theory. Using this basis in understanding the electronic structure of huge molecules, he will work toward developing a novel approach for predicting reaction pathways and products. In this regard, Dr. Ayers’ work is broadly viewed as groundbreaking.

There is currently no way to use computations to predict the reaction mechanisms or the products of reactions. These types of computational tools are required to enable the design of advanced pharmaceutical agents that bind to proteins and either inhibit the action of a specific enzyme or block the site where protein-protein interactions occur. It is essential to understand how proteins work at the atomic level in order to design drugs that meet specific needs and do it well. By the same token, understanding how things work at the atomic level can enable scientists to design new industrial catalysts that are also both highly targeted and highly effective.

Dr. Ayers’ research holds the potential for developing a practical, reliable and broadly applicable method for predicting the products and detailed reaction mechanisms of chemical reactions that will generate substantive advances in molecular biology and material design.

Analyzing and critically examining the policies and institutions governing the ownership, funding, and control of communication.

The rise of digital media has dramatically altered the global political landscape. Sara Bannerman is examining how this new environment is reshaping the future of international copyright, cultural funding, and communications policy and governance. Her work on intellectual property and international copyright has traced the history and future trajectories of copyright in Canada and on a global scale.

While most copyright research is focused on powerful countries, Bannerman’s work highlights the roles of emerging countries, non-governmental organizations, and indigenous peoples in the history and future of international copyright. Instead of focusing on ownership, she focuses on users’ rights in the education, news reporting, scientific and translation contexts.

A specialist in communications studies, Bannerman is ideally positioned to undertake this challenge. She is the author of two books, International Copyright and Access to Knowledge (CUP, 2016) and The Struggle for Canadian Copyright: Imperialism to Internationalism, 1842-1971 (UBC, 2013). Bannerman’s work contributes to a deep understanding of the political stakes and divisions raised by copyright policy both nationally and internationally.

Bannerman notes that cultural policies are increasingly governed not only by powerful states but also through networks, and she explores this by examining online crowdfunding and other networked models of authorship and participation as tools for reshaping creativity and cultural production.

Bannerman’s research on intellectual property issues will provide greater insight into the stakes involved – for creators and other users – in the new politics, new forms of authorship, new forms of labor, and new forms of governance that new technologies and globalization raise.

Studying musculoskeletal trauma and surgical outcomes.

Trauma is the leading cause of death in the first four decades of life surpassed only by cancer and atherosclerosis as the major cause of death in all age groups. For every death attributable to trauma, three patients survive but are permanently disabled. With over 60 million injuries per year in North America, approximately 50 percent require medical care, of which 8.7 million patients are temporarily disabled. Trauma-related care costs over 100 billion dollars annually. Yet, despite these staggering costs, only four cents for every dollar is spent on trauma research.

The care of patients with musculoskeletal injuries has been guided by physician opinion since quality research in this area has been limited. Dr. Mohit Bhandari and his colleagues at McMaster University are changing the paradigm of “eminence-based practice” to “evidence-based practice.”

In his search for evidence, Dr. Bhandari has been co-leading a collaborative multicentre randomized trial of alternative operative techniques in patients with tibial shaft fractures – the most common long fracture. The study is setting a benchmark in the conduct of orthopaedic trials worldwide.

As the Canada Research Chair in Musculoskeletal Trauma and Surgical Outcomes, Dr. Bhandari has developed a research program that meets the need for high quality surgical research aimed at answering clinical questions of international importance.

His research includes the design and conduct of large, multicentre randomized trials that evaluate interventions in patients with musculoskeletal injuries. In addition, his program explores the methodological issues specific to the conduct of surgical trials and involves the application and evaluation of evidence-based methods to guide the care of patients with musculoskeletal trauma. In the process, his program is attracting and educating new surgical trainees as career academic surgeons.

Discovering why our immune system changes with age and how this predisposes us to respiratory infections.

Upper respiratory tract infections, such as pneumonia and influenza, are a leading cause of deaths among the elderly and a precipitating factor in their declining health. The efficacy of the most common treatment – antibiotics – could be more effective if we combined it with immune modulating drugs to combat some of the changes to the aging immune system.

Dawn Bowdish, an associate professor of Pathology and Molecular Medicine, leads an ambitious and innovative research program that is questioning longstanding assumptions about the aging immune system.

One of those assumptions is that old people get sick because their immune systems don’t work. Not true, says Bowdish. They just work differently.

It is widely known that as we age we become more inflamed. Bowdish found that the higher levels of inflammation in 2 year old mice (about the same as a 75 year old person) caused some types of white blood cells to enter the bloodstream before they were fully mature and produce even more inflammation.

While small amounts of inflammation are required to fight infections like pneumonia, the old mice produced so much that their white blood cells were less effective. Reducing levels of inflammation helped them to clear the infection and get better.

This may help explain why older adults with pneumonia do better when given corticosteroids, to reduce inflammation in addition to antibiotics. It may also reveal why chronic inflammatory diseases such as diabetes, cardiovascular disease, and dementia – all characterized by having elevated levels of pro-inflammatory cytokines – carry an increased risk for acquiring pneumonia.

Understanding the interplay between age, inflammation and anti-bacterial impairment could lead to the development of preventative and therapeutic strategies that will keep us all living longer and healthier.

Investigating the behavior of biomolecules within sol-gel-processed glasses and composites, in order to develop a fundamental molecular-level view of the biomolecules, and to build devices such as sensors and chromatography columns.

Chemical Biology is vital to many established and emerging industrial sectors. In particular, new ventures based on genomics and proteomics will benefit from chemical biology the most.

The interaction between chemists and biochemists is a cornerstone of Dr. John Brennan’s research program. Much of his work is in the entrapment of biomolecules into sol-gel derived glasses, which leads to development of improved bioanalytical devices. His work intertwines materials science, biochemistry and analytical chemistry in a unique manner to produce new assays and analytical devices that have the potential to revolutionize the areas of biosensing and drug discovery. The goal of his research group is to become a world leader in the development of advanced sol-gel based biomaterials, biosensor technologies and high-throughput drug screening platforms.

As Canada Research Chair in Bioanalytical Chemistry, Dr. Brennan will use a highly interdisciplinary approach to enable him to achieve his research goals of: developing new matrixes for the immobilization of functional biomolecules; the development of improved analytical devices based on sol-gel immobilized biomolecules, and; the extension of the range of biomolecules that can be used for sensing and screening purposes. Advances in these areas have the potential to spin out new commercial products and new companies, to lead to improved point-of-care diagnostic devices, and to revolutionize drug-screening technologies. Dr. Brennan is already negotiating licensing agreements with Canadian companies for sol-gel based assay methods.

Dr. Brennan’s research is backed by the world-class Brockhouse Institute for Materials Research (BIMR) at McMaster University. The institute, along with the university’s initiative in developing a new graduate program in Chemical Biology, will put Dr. Brennan and his colleagues in a position to make the required leaps forward in sensor development and drug discovery that are not likely to occur anywhere else in Canada, and at only a handful of highly funded laboratories in the U.S.

The experiences and effective management of contingent (non-permanent) workers, how employees interpret and respond to electronic communication, why employees hide knowledge from their coworkers, and workplace stress of leaders.

Our work can define us, engage us, take up tens of thousands of hours of our life, and is often the first subject of conversation among new acquaintances who want to know “What do you do?” followed by “Where do you work?”

Canadian workers and the organizations that employ them are faced with an ever increasing set of challenges. Permanent full-time jobs that last for an entire career are becoming increasingly scarce, while independent contractors and temporary workers are more commonplace; even the most important office communications aren’t happening across a desk, but via computer keyboards and smart phone screens; and stressed workers respond to increasingly competitive work environments with knowledge hiding even between coworkers in the same organization.

These transformations in the Canadian workplace are at the heart of Catherine Connelly’s interdisciplinary research program, which analyzes and considers the implication of these changes for workers and for organizations.

By extending mainstream organizational behaviour and psychological theories, Connelly will use her Canadian Research Chair in Organizational Behaviour to discover the true costs to organizations that hire contingent workers, identify the cues that determine how individuals react to – and interpret – electronic communications, and study the conditions, attributes and processes that result in knowledge hiding behaviours. Connelly will also examine how leaders can deal with the high-stress work environment while still maintaining their effectiveness.

Connelly’s research will help to improve the information, communication, training and guidance available to workers and organizations in Canada, in the context of rapid and significant workplace challenges.

Canada Research Chair
Translational Research in Long-Term Care

Endowed Research Chair
Schlegel Chair in Clinical Epidemiology and Aging

Canada Research Chair
Perioperative Medicine

Endowed Research Chair
McMaster University / Hamilton Health Sciences Chair in Perioperative Care

Canada Research Chair
Electrified Transportation and Smart Mobility

Design and optimization of the next generation of cost-effective and smart, energy-efficient electrified vehicles to reduce greenhouse gas emissions and improve performance.

Conventional vehicles are harmful to humans as well as the environment, and serious changes are needed to reduce dependency on fossil fuels. To address this, engineers worldwide are competing to build the next generation of cost-effective and smart, energy-efficient cars. Plug-in hybrid and electric vehicles are set to become one of the main forms of transportation nationally and globally by 2030.

Internationally recognized for his work in vehicle electrification research, Dr. Ali Emadi is working to improve the efficiency, performance, and cost-effectiveness of electrified power trains, powertrain components, and vehicle energy management systems. He held the Canada Excellence Research Chair in Hybrid Powertrain, and is the Canada Research Chair in Electrified Transportation and Smart Mobility.

Dr. Emadi and his team will continue to build on their previously established framework to develop and optimize electrified power trains and powertrain components including power electronic converters and electric propulsion motors.

A typical electrified vehicle will reduce greenhouse gas emissions significantly compared to its internal combustion counterpart. This research will bring new, energy-efficient, and environmentally friendly solutions to the market faster. This will enable higher performance, lower cost, reduced and zero emission vehicles to be on the roads sooner, and thus help reach Canada’s greenhouse gas emission reduction targets for 2020-2030.

Canada Excellence Research Chair
Canadian Excellence Research Chair Laureate in Hybrid Powertrain

The harmful effects that vehicle emissions have on both human health and the environment are leading to major shifts in the global automotive industry.

Engineers around the world are competing to build the next generation of cost-effective, energy-efficient cars.
Before joining McMaster University, Ali Emadi was the Harris Perlstein Endowed Chair Professor of Engineering and director of the Electric Power and Power Electronics Centre and Grainger Laboratories at the Illinois Institute of Technology. He also founded and served as president of the spin-off company Hybrid Electric Vehicle Technologies.

Emadi is internationally recognized for his in-depth research on hybrid electric vehicle powertrains and electric drives. He holds a PhD in electrical engineering, with a specialization in power electronics and motor drives, from Texas A&M University. He received a bachelor’s and master’s degree in electrical engineering from Sharif University of Technology, Iran.

An extremely active researcher, Emadi has authored over 250 publications and conference papers, as well as several books, and has served as guest editor-in-chief on several publishing committees for the Institute of Electrical and Electronics Engineers. He has been awarded several patents, including one for a energy-efficient, digitally controlled electric motor that is available to appliance manufacturers at a lower cost than earlier motors.

At the forefront of this competition are plug-in hybrid and electric vehicles. Responding to the needs of a growing population of energy-conscious consumers, plug-in vehicles are expected to become one of the main forms of transportation in Canada and across the globe by 2030.

One of the keys to engineering the next generation of hybrid electric cars will be improving their powertrain, which transmits propulsion power. Canada Excellence Research Chair in Hybrid Powertrain Ali Emadi is at the leading edge of new developments in transportation electrification, including advanced electrified powertrains; the vehicle-to-grid interface of plug-in vehicles with Smart Grid technology; powertrain components; hybrid battery/super-capacitor energy storage systems; and adaptive vehicle control and power management systems.

Emadi’s research provides solutions for industry and environmental policy-makers alike: it meets the current demands of the automotive sector and will further the growth of Canada’s economy, while maintaining a strong position for the future of Canada’s green technology industry.

A rising star in his field, Emadi’s work has already had exceptional impact. His experience and knowledge aligns well with the existing engineering expertise at McMaster University, where hybrid automobile research and development is already heavily supported.

NSERC Industrial Research Chair
NSERC/FCA Industrial Research Chair in Electrified Powertrains

Partnering with Indigenous communities to explore and address health and well-being issues, and examine the impact of digital technology in these communities.

Indigenous peoples in Canada face continued suffering as a result of colonialism. Among the many consequences is the erosion of intergenerational closeness, particularly between the youngest and oldest members of society.

Chelsea Gabel, Canada Research Chair in Indigenous Well-Being, Community-Engagement, and Innovation, is studying these relationships and her work shows that Indigenous community members are aware of the weakening of elder-youth relationships, and that there is both a need and a desire to restore them.

Some Indigenous communities are turning to technology to help improve their conditions; digital technology can boost community capacity, affirm Indigenous identity, and disseminate culturally relevant information. It can also be used to enable intergenerational engagement, empowering elders who want important information to be available to youth, and empowering young people as agents in the preservation of unique Indigenous knowledge.

Gabel is exploring the theoretical and practical impacts of technology deployment in an Indigenous context. She and her team will assist in engaging elders and youth in discussions about healthy living, Indigenous Knowledge, and preserving community connections. This program of research recognizes that the well-being of these two groups is closely linked, and that the process of digital technologies being reimagined as creatively engaged tools of healing and empowerment can bring elders and youth together to address the challenges they face.

Addressing these issues will lead to the development of elder/youth initiatives and policies that will improve the quality of life in First Nations, Inuit and Métis communities across generations.

Studying the intersection of leadership, work attitudes, and performance, particularly in the contextual performance of nurses.

What makes some nurses willing to go that extra mile in their work? If we can learn more about leader-follower relations in the nursing profession it will help us design more effective leadership development programs, which will in turn increase efficiencies and cost savings and ultimately improve patient care.

As the Canada Research Chair in Organizational Behaviour and Human Performance, Rick Hackett is making innovative contributions to the field of leadership generally and to leadership in nursing specifically. He is examining the intersection of leadership, work attitudes and employee performance, in the little-studied area of contextual work performance, that is on-the-job behaviour that goes beyond the call. His work represents the first research into the reciprocal behaviour exchanges that go on between supervisors and nursing practitioners that yield extraordinary performance.

Hackett is undertaking a literature review and carrying out longitudinal research to learn more about leader-follower relations, including how leadership affects mental health, attitudes, and performance. He is also working on a book for nursing professionals interested in leadership positions and how to build relationships with direct reports. In addition, he hopes to establish a pioneering centre for leadership research and development in the health-care sector to disseminate research, sponsor publications and seminars, and provide leadership development workshops.

The Canada Research Chair builds on Hackett’s involvement with the Quality of Nursing Work Life Research Unit in health sciences and the graduate Health Services Management Program in the business school at McMaster University. His research there includes the study of absenteeism, job satisfaction (especially among nurses), leadership, and organizational commitment.

Studying the intersection of leadership, work attitudes, and performance, particularly in the contextual performance of nurses.

What makes some nurses willing to go that extra mile in their work? If we can learn more about leader-follower relations in the nursing profession it will help us design more effective leadership development programs, which will in turn increase efficiencies and cost savings and ultimately improve patient care.

As the Canada Research Chair in Organizational Behaviour and Human Performance, Rick Hackett is making innovative contributions to the field of leadership generally and to leadership in nursing specifically. He is examining the intersection of leadership, work attitudes and employee performance, in the little-studied area of contextual work performance, that is on-the-job behaviour that goes beyond the call. His work represents the first research into the reciprocal behaviour exchanges that go on between supervisors and nursing practitioners that yield extraordinary performance.

Hackett is undertaking a literature review and carrying out longitudinal research to learn more about leader-follower relations, including how leadership affects mental health, attitudes, and performance. He is also working on a book for nursing professionals interested in leadership positions and how to build relationships with direct reports. In addition, he hopes to establish a pioneering centre for leadership research and development in the health-care sector to disseminate research, sponsor publications and seminars, and provide leadership development workshops.

The Canada Research Chair builds on Hackett’s involvement with the Quality of Nursing Work Life Research Unit in health sciences and the graduate Health Services Management Program in the business school at McMaster University. His research there includes the study of absenteeism, job satisfaction (especially among nurses), leadership, and organizational commitment.

Using symplectic and algebraic geometry techniques to help visualize and analyze shapes beyond the second dimension.

From ancient civilizations to modern times, human minds have consistently pondered the question: What is the shape of the universe in which we live?

An understanding of the physical universe requires us to be able to “see” shapes in higher dimension, but most of our day-to-day experiences are limited to two-dimensional representations of three-dimensional objects.

Mathematician Megumi Harada’s research helps people get around this problem. Her specialty is equivariant symplectic and algebraic geometry, a branch of geometry involving the study of symmetries of spaces with symplectic and/or algebraic structures.

She uses mathematical techniques in one- and two-dimensional situations, then generalizes those techniques, making it possible to analyze, in a concrete way, “shapes” in higher-dimensional spaces. Some examples of these techniques include gluing, direct products, fiber products, connect sum, and stereographic projection.

Symplectic geometry was originally developed to provide a mathematical framework for classical mechanics. In the 20th century, it developed into a mathematical theory, with applications to various aspects of physics, such as string theory and conformal field theory.

Algebraic geometry is the study of systems of polynomial equations and the geometry of their solutions. Algebraic geometry has many applications, including quantum computing, cryptography, and image and signal processing.

Harada works at the interface of symplectic geometry, algebraic geometry, geometric representation theory and algebraic combinatorics, and her research has potential applications outside of pure mathematics.

A particular focus of Harada’s current research is the “hot” new theory of Newton-Okounkov bodies. This theory builds upon the convex geometry of polytopes, which has applications in optimization theory. Harada intends to further develop this theory to further connect these research areas and potentially lead to new breakthroughs in applied mathematics.

Using translational research methods to explore the role of ATP-binding cassette (ABC) transporters in mucosal immunology.

It’s hard to imagine, but we inhale over 10,000 litres of potentially harmful air every day – for 4 million Canadians living with chronic respiratory diseases, such as asthma, the consequences are frightening, if not devastating: from airway constriction to hospital visits to untimely death.

Compared to a healthy individual, an asthmatic’s respiratory system is crucially different; asthmatics have a greater risk for airway inflammation, they produce an excess of mucus, and are more susceptible to allergens.

Epithelial cells line cavities and surfaces of organs throughout our bodies. Airway epithelial cells are especially important because they help protect against inhaled environmental insults. However, secretions by these cells in individuals with chronic respiratory diseases lead to increased airway inflammation – a big problem for those already finding it hard to breathe. Luckily, Jeremy Hirota’s research can help us catch our breath.

Jeremy Hirota, Canadian Research Chair in Respiratory Mucosal Immunology, is at the forefront of research into how ABC transporters – a protein superfamily that transports substances across membranes – impact the respiratory system. Hirota and his research team will continue to characterize ABC transporters by conducting translational experiments in vitro with human cells, and in vivo using live mice.

Hirota’s research will expand the existing body of knowledge by providing evidence that links ABC transporters to chronic respiratory diseases, boosts the development of ABC inhibitors, and, ultimately, leads to new and innovative treatments for respiratory diseases including asthma, cystic fibrosis, and chronic obstructive pulmonary disease.

Developing new ‘smart’ materials and nano-medicines that will provide targeted drug delivery with fewer side effects for patients suffering from cancer and other diseases.

Todd Hoare has discovered that the best things come in small packages.

The Canada Research Chair in Engineered Smart Materials is studying the use of gel nanoparticles that can get drugs to the place they need to be in our bodies at the rate they need to be delivered for the best therapeutic effect.

He works on the nano-scale, creating tiny polymer delivery vehicles that act as containers for drugs that fight disease, infection or tumors. These ‘smart’ hydrogels react to various stimuli (heat, pH, light and electromagnetic fields, for example) causing them to release their drug only at the desired site of action and at user-controlled doses.

The remote-controlled drug delivery vehicles can be activated reversibly and non-invasively to trigger enhanced or suppressed drug release in the body on demand, reducing side effects and improving the efficacy of therapies for treating cancer, schizophrenia, and ocular disease, among others. They can also be precisely tuned to elicit different cellular responses and, as such, hold great promise for tissue regeneration.

Working at the interface of polymer science, physical chemistry, and biology, Hoare’s research will add significantly to our fundamental understanding of the chemistry and physics of smart materials and lead to the development of new applications in other technologies, including food, nutriceutical delivery, and environmental applications, such as soil and water remediation.

Using early in-bed cycling for mechanically ventilated patients while in the intensive care unit (ICU) to improve patient outcomes.

Exercising in the Intensive Care Unit? It’s a concept that seems at odds with the typical ICU where recovery for the hospital’s sickest patients often means prolonged bed rest, sedation, and constant monitoring and support from specialized equipment.

But exercising critically ill patients might be ‘just what the doctor ordered’ – a remedy that’s at the heart of rehabilitation scientist Michelle Kho’s Canada Research Chair in Critical Care Rehabilitation and Knowledge Translation. Her research seeks a solution for the high cost of convalescence, not only in quality of life for ICU survivors, but the financial burden for the health care system, where critical care is our most costly hospital service.

As a practicing physiotherapist and researcher, Kho’s ‘lab’ is the ICU, where she works with highly specialized health care teams to help patients not only survive their life threatening illness or injury, but improve their recovery time and promote continued health and well-being once they leave intensive care. Kho’s research program –Critical Care Cycling to Improve Lower Extremity Strength (CYCLE) – focuses on preventing or reducing the adverse effects of immobilization by having patients pedal a motorized stationary bicycle affixed to their ICU bed.

Dr. Kho’s CYCLE rehabilitation regime targets ICU patients needing breathing machines in the very first week of critical care, when muscle strength in their legs can melt away by 15% or more. By strengthening their muscles and their overall health, patients have a better chance of not only surviving their critical illness, but may be sent home sooner, stronger, and happier, not only benefitting the patient, but alleviating the high cost of critical care for our health care system.

Canada Research Chair
Patient Reported Outcomes

CIHR Sex and Gender Science Chair – Gender Methods and Measures
Canadian Institutes of Health Research

Studying experiences with, and impacts of, innovative strategies that support evidence-informed health systems.

Health system policymakers and stakeholders grapple with complex decisions about health systems every day. Poor decisions translate into fatalities, lower quality of life and poor satisfaction among patients and their families, and wasted investments and opportunities for the citizens who pay for the system.

The last decade has been called the ‘health systems decade’ as governments like those in Canadian provinces, international agencies like the World Health Organization (WHO), and donors like the Gates Foundation, come to realize that health-system arrangements determine whether the right mix of cost-effective programs, services, and drugs get to those who need them, and at an acceptable cost.

Synthesized high-quality research evidence can inform decisions about these health system arrangements and implementation arrangements. However, policymakers and stakeholders often do not consider this research evidence alongside the institutional constraints, interest group pressures, values, and other factors that drive the policymaking process.

John Lavis, Canada Research Chair in Evidence-Informed Health Systems, is working to change this. He wants to help create the evidence base about which strategies best support an evidence-informed health system given the particular contexts and issues policymakers and stakeholders face.

Ultimately, access to high-quality research evidence can help policymakers and stakeholders set agendas, take well-considered actions, and communicate the rationale for actions effectively.

Applying observational and experimental methods to examine pre- and early post-natal stressors and their impact on brain development.

Nearly half of all adults experience some form of mental illness at some point in their lives, and nearly half of those individuals are likely to have had mental disorders as children. Unfortunately, mental illness is often not diagnosed early, and few individuals actually receive treatment.

Although the mediators in of emotion regulation and cognitive functioning develop in the womb, psychiatric research tends to examine risk factors occurring in childhood and later. Ryan van Lieshout, Canada Research Chair in the Perinatal Programming of Mental Disorders, is looking to change that. He’s exploring perinatal risk factors and developing interventions aimed at these to promote life-long mental health.

Dr. van Lieshout will use longitudinal observations of extremely low birth weight survivors, and experimental methodologies, to test the developmental origins of health and disease hypothesis.

Prenatal interventions are especially important to combat mental illness since some of the most powerful predictors of later life mental illness occur during this time: preterm birth, poor maternal diet, and maternal mental illness. Interventions undertaken during pregnancy and/or the early postnatal period are also ideal because women are more likely to make positive changes compared to any other point in their life, and are in regular contact with healthcare professionals.

This research will lead to the development of perinatal interventions designed to optimize early brain development, and aim to prevent psychiatric problems in offspring, helping them stay healthy throughout their lives.

Canada Research Chair
Translational Addiction Research

Endowed Research Chair
Peter Boris Chair in Addictions Research

Understanding, highlighting, and combating the risks of maternal and infant obesity.

Half of all Canadian women of childbearing age are overweight or obese, and more than half gain too much weight during pregnancy. Both can lead to serious complications for themselves and their babies, including stillbirth.

For the baby, pre-pregnancy obesity increases the risk of premature birth; excess weight gain during pregnancy (PWG) is associated with high infant birth weight which in turn is associated with a doubling of the risk of obesity in childhood.

Sarah McDonald, an expert in perinatal research, is working to highlight the risks of maternal and infant obesity, understand who is most at risk, and develop interventions to promote healthy weight gain and, ultimately, improve the physical and mental well-being of women and their children.

A clinical epidemiologist and professor of obstetrics and gynecology, she led a meta-analysis of 84 studies involving more than one million women. It found overweight or obese women have a 30 percent greater risk of induced preterm birth before 37 weeks and that risk climbs to 70 percent for very obese women.

It was solid evidence of the seriousness of the relationship between obesity and pre-term birth, and now most obstetrical societies recognize these risks as well as the risks of excess weight gain during pregnancy.

McDonald’s findings pose serious public health implications for Canada and other countries in both the developed and developing world where maternal obesity rates are high. Prevention and early intervention is key. She is now seeking to identify new approaches to motivate mothers-to-be to have as healthy lives as possible during the important window on their infant’s health: pregnancy.

Examining the effects of very low doses of radiation on human and non-human species, with particular emphasis on the mechanisms of low-dose effects.

Radiation is everywhere. Rocks produce a natural form called radon. Anyone who has had a chest or dental X-ray has been exposed to man-made radiation. And highly sophisticated medical imaging techniques are used to treat life-threatening deformities or diseases. Yet most of us are frightened of radiation because we’ve heard about the terrible effects of high doses experienced during atomic bomb explosions or nuclear reactor meltdowns. This level of exposure, however, is never even approached during the controlled use of radiation where strict regulations are in place to ensure safety. Still the question remains: Just how dangerous are low doses?

Canada Research Chair Dr. Carmel Mothersill is a radiobiologist who has studied low-dose radiation effects for several years. In her research, she studies the effects of low-dose exposures to cells derived from humans and other species. She is interested in the long-term changes in the behaviour of cells; changes, for example, in how they grow and how they communicate. The information derived from her research helps put radiation risks in context given the benefits of the medical use of radiation. In addition her research is used to help detect potential problems by using sensitive tests that employ cultured cells and small tissue explants and do not involve experiments on animals.

Dr. Mothersill’s research suggests that low doses of radiation have very different effects compared to high doses. Cells appear to be able to adapt to low doses and to organize cell and tissue responses through sophisticated communication systems. The death of one or two cells in the population, which could be a consequence of low-dose exposure, is therefore not a problem for the tissue. As she explores this issue, Dr. Mothersill is also looking at the relative sensitivities of individual humans and non-human species to low-dose exposures to see if any are extra-sensitive and whether exposure to a little radiation is dangerous.

Canada Research Chair
Geroscience

This research on aging will answer questions that are relevant to decision-makers and improve the quality of life and health of older Canadians.

We all look forward to aging in good health. By the time 2025 rolls around, it’s estimated that one in every five Canadians will be aged 65 or over – ‘senior’ citizens hoping to lead active and independent lives in their communities.

Some people age in a healthy fashion despite many physical health challenges, while others who are in good physical health age less optimally. What explains this phenomenon?

Dr. Parminder Raina, Canada Research Chair in Geroscience, is leading the Canadian Longitudinal Study on Aging (CLSA) which aims to answer this and many other questions about aging. The study brings together the capacity, knowledge and expertise of experts in the physical, psychological and social health fields to unlock some of the greatest mysteries of aging that have the most impact on the health of Canadians.

The CLSA is a large, national, long-term study that will follow approximately 50,000 Canadian men and women between the ages of 45 and 85 for at least 20 years. It will collect information on the changing biological, medical, psychological, social and economic aspects of their lives. This platform of research is designed to be a legacy cohort for all researchers and it is the largest and most comprehensive research platform on aging anywhere in the world.

Raina and other researchers are studying these factors, both individually and in combination, to understand how they have an impact in maintaining health and in the development of disease and disability as people age. This information will help identify ways to prevent disease and improve health services, and will facilitate the rapid adoption of extensive research into health practice, programs and policies.

Raina’s research will result in a strengthened and more responsive health system that will improve the quality of life for all Canadians.

Endowed Research Chair
Raymond and Margaret Labarge Chair in Research and Knowledge Application for Optimal Aging

Dr. Karen Robson works together with the Toronto District School Board to look at issues around the transition of high school students to postsecondary education in Ontario. She leads a large research team, which includes members in Chicago, New York City, London, Vancouver, and Toronto. With a strong commitment to longitudinal and comparative research, Dr. Robson examines the educational pathways of young people in major cities around the world, using policy contexts to understand major differences in where young people end up after high school.

Using experimental and preclinical methods to understand the links between immune and metabolic systems.

Metabolic diseases can lead to complications like heart attacks, stroke, and even infection, claiming millions of lives worldwide each year. Obesity, which increases blood insulin and glucose, is a significant factor in the development of metabolic diseases like prediabetes and type 2 diabetes. Over half of Canada’s population is overweight or obese and potentially at risk.

Researchers aren’t sure why, but not all obese individuals will develop a metabolic disease. Thankfully, Jonathan Schertzer, Canada Research Chair in Metabolic Inflammation, is trying to get the skinny on it.

Most people who develop prediabetes will later develop type 2 diabetes, but this process could take decades. Prediabetes is reversible so it is crucial to use that window of time to prevent the onset of type 2 diabetes.

Schertzer and his research team are using experimental and preclinical approaches to understand the link between the immune and metabolic systems. They will also examine how existing drugs impact blood glucose.

By understanding how our bodies interact with bacteria and therapeutic drugs during obesity, and how inflammation is triggered, Schertzer’s research team aims to improve the safety and success of existing therapies and promote the development of new and innovative treatments for obesity-related diseases.

This work focuses on how physiological systems function during environmental stress, how they are shaped during development, and how they evolve.

Scott – an assistant professor in the department of biology is examining how hypoxia-tolerant animals have solved the problems associated with oxygen deprivation, which will then provide perspective on issues related to human health (diseases involved oxygen limitation such as COPD and cardiovascular disease) and the environment (climate change and pollution).

Endowed Research Chair
Juravinski Thoracic Surgery Professorship

Endowed Research Chair
Mortgage Intelligence/GMAC Residential Funding of Canada Chair in Thoracic Surgery

The development of new technologies and drug formulations to improve the delivery of medication to both the front and back of the eye.

More than a million Canadians live with vision loss, a number that’s expected to double over the next 25 years as the population ages.

New drugs are revolutionizing treatment, but their effectiveness is limited by complications and patient compliance. Less than 5% of those who can wear contact lenses don’t because of discomfort. Implanted lenses, used to restore sight after cataract surgery, cause secondary cataracts in 4 out of 10 patients. Topical eye drops, even when used as directed, shed their active ingredients within seconds.

Heather Sheardown, a chemical engineering professor and world-renowned expert in ophthalmic biomaterials, uses the tools of chemical biology (high-throughput synthesis and screening) to improve the odds for those afflicted with a host of ocular conditions.

Her research is focused on developing new drug-containing formulations that can be delivered as topical drops to provide long lasting and efficacious delivery of drugs to the front of the eye, as well as the next generation of smart materials that interact with the ocular tissues to promote the long term delivery of drugs to the back of the eye.

The founding director of the 20/20 NSERC Ophthalmic Materials Research Network has already made significant contributions. Her research group has designed special contact lenses and better eye drops to assist in drug delivery, and developed a microneedle system that spares patients the excruciating routine of having drugs injected into their eyes by syringe every six to eight weeks.

Sheardown’s work holds enormous potential for delivering personalized drug formulations that could brighten the outlook for millions of people afflicted with ophthalmic diseases.

Focusing on further characterization of genetic abnormalities of brain tumor initiating cells (BTICs), with the intent of developing future therapies that will target BTICs, and provide insight into patient prognosis.

It was while Dr. Sheila Singh, Canada Research Chair in Human Cancer Stem Cell Biology, was in medical school that two little boys with brain tumours—both named Christopher—sowed the first seeds of her interest in research. Both were five years old and treated with the best current therapies. One flourished. The other died.

Singh says the boy who died left her a legacy of questions: Why should two small boys with the same disease fare so differently? What is different about each individual’s tumour?

As a scientist in McMaster University’s Stem Cell and Cancer Research Institute, Singh now spends her life looking for the molecular and genetic answers to these questions.

She’s discovered an abnormal stem cell—the brain tumour initiating cell (BTIC)—that may drive the formation of brain tumours. It’s the first isolation of cancer stem cells in the central nervous system—a discovery with important implications for understanding how brain tumours start.

Most important to Singh’s research is the idea that only a small population of cancer stem cells, and not every cell in a brain tumour, is capable of generating and propagating. Current approaches to brain tumours focus on every cell in the tumour rather than on the rare tumour stem cell, and this may explain the poor response of brain tumours to current treatments. Future therapies that target the BTIC could better halt the growth and propagation of tumours.

Singh and her team will continue to search for better surface markers for the BTIC, making it possible to isolate the cell even more specifically and easily. Her work will offer insight into patient prognosis, as patients with a higher proportion of BTICs may have a shorter survival and worse prognosis. Her studies will form the basis for future trials of therapy directed against the BTIC.

Developing low-cost, miniaturized devices that can be used at point-of-care and in the field to quickly and accurately diagnose disease.

What if cancer, infectious diseases and other conditions could be diagnosed in a matter of hours instead of weeks during a regular visit to your family doctor? Or if paramedics could use a simple finger prick to analyze a heart attack victim’s blood and transmit that information to hospital before the patient’s arrival?

Point-of-care diagnostic testing promises to usher in a new era of predictive, personalized, and preemptive medicine by bringing complex diagnostic and screening tests, currently performed at centralized laboratories, to local clinics, physician offices, and patient and community homes. Yet only a few systems have made it from the research lab to market.

Leyla Soleymani, Canada Research Chair in Miniaturized Biomedical Devices, is developing new fabrication processes, materials, and devices that will enable the rapid development and commercialization of application-specific, handheld, point-of-care diagnostic systems.

She employs ink-based fabrication methods to create structurally-tuned solid-phase electronics functionalized with bio-receptors. This allows multiple biomedical devices for processing clinical samples and detecting genetic markers to be miniaturized and created on a single scalable and inexpensive system.

Her research has already contributed to a novel biosensor that improves the detection of viruses and bacteria. Dubbed as the most sensitive nanostructured biosensing chip of its kind, the device’s probes can identify whether a particular disease exists within the body with the utmost precision and within only 30 minutes.

Offering sensitive, specific, low-cost, and easily-accessible disease diagnosis, prognosis, and treatment selection capabilities at the point-of-need, promises significant health care benefits for under-served populations in Canada and resource-poor communities in the developing world.

Canada Research Chair
Metabolisim, Obesity, & Type 2 Diabetes

Understanding how hormones regulate the body’s storage and breakdown of fat and its response to insulin.

Canadians eat too many fast foods and don’t exercise enough. With obesity contributing to escalating rates of diabetes and heart disease, it’s a recipe for disaster.

At the molecular level, Dr. Gregory Steinberg, Canada Research Chair in Metabolism, Obesity and Type 2 Diabetes, is working to understand how obesity causes Type 2 diabetes and the role nutrition and exercise play in maintaining good health.

To accomplish this, he is conducting metabolic studies in which genetically modified mice exercise or consume calorie foods. How many and what type of calories (fat or carbohydrate) the mice burn will be measured both during exercise and in response to hormones.

Steinberg’s studies will be complemented with work using advanced techniques in protein chemistry and molecular biology with an emphasis on phosphoproteomics (identifying, cataloguing and characterizing proteins) and gene expression analysis.

Steinberg is also interested in understanding the role of inflammation in obesity and how this contributes to the development of insulin resistance and atherosclerosis.

The goal of Steinberg’s research is to develop medicines that could be used to treat insulin resistance and atherosclerosis, both serious problems for the more than one million diabetics living in Canada.

Endowed Research Chair
J. Bruce Duncan Chair in Metabolic Diseases

Dr. Arthur Sweetman, a leading researcher in health and labour economics, was named in February 2010 as the new Ontario Research Chair in Health Human Resources at McMaster University. Specializing in health and labour economics, Dr. Sweetman focuses on issues in health human resources in Ontario, including the shortage in doctors, health budgets, and the number of medical radiation technologists and pharmacists needed in the province.

Throughout his extensive academic career, Dr. Sweetman has demonstrated leadership in research, teaching, and bridging academia and policy-making. His extensive research in immigration and education policy compliments his work in health human resources, for which work-place training and immigration are integral parts of workforce strategy.