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Therapeutics & Diagnostics 23-034

Stabilization of biological and chemical species during pasteurization

A) Spray dried powder composed of B) sugar microparticles with C) encapsulated bacteria-killing viruses within. The easy-to-use powder can be applied for bacterial contamination intervention.

Tech ID



M. Gomez
Z. Hosseinidoust
C. Filipe

Patent Status

US provisional patent filed

Stage of Research

Proof of principle data available


Amy Hector
Business Development Manager


Various food products require additives such as prebiotics, probiotics, or natural preservatives, most of which are extremely sensitive to elevated temperatures during food processing, such as pasteurization. For example, several bacteriophages have been recognized to reduce bacterial growth in foods but are not stable during food processing [1]. Therefore, a protection system to stabilize bacteriophages and other biological and chemical species is needed.

Researchers at McMaster with expertise in stabilization technologies [2-4] have developed a multi-component system to protect biological and chemical species from degradation due to exposure to challenging conditions such as high/low temperatures.


  • Can be used therapeutically and prophylactically at every step of the food production and distribution chain for food safety.
  • Environmental bioremediation and/or prophylaxis and medical use.
  • Protect against heat excursions during storage and transportation.
  • Potential to offer protection against other chemical or physical challenges such as pH or mechanical stress.


  • Effective in both a liquid and dry environment.
  • Reduce product loss and outbreaks.


  1. Ahmadi H, Radford D, Kropinski AM, Lim LT, Balamurugan S. Thermal-stability and reconstitution ability of Listeria phages P100 and A511. Front Microbiol. 2017;8(DEC):1–11.
  2. Leung V, Groves L, Szewczyk A, Hosseinidoust Z, Filipe CDM. Long-Term Antimicrobial Activity of Phage-Sugar Glasses is Closely Tied to the Processing Conditions. ACS Omega. 2018;3(12):18295–303.
  3. Leung V, Szewczyk A, Chau J, Hosseinidoust Z, Groves L, Hawsawi H, Anany H, Griffiths MW, Ali MM, Filipe CDM. Long-Term Preservation of Bacteriophage Antimicrobials Using Sugar Glasses. ACS Biomater, 2018: 4, 3802-3808.
  4. Jahanshahi-Anbuhi S, Pennings K, Leung V, Liu M, Carrasquilla C, Kannan B, Li Y, Pelton R, Brennan JD, Filipe CDM. Pullulan Encapsulation of Labile Biomolecules to Give Stable Bioassay Tablets. Angewandte Chemie, 2014;53(24): 6155-6158

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