Abstract

Apoptosis signal-regulating kinase 1 (ASK1), a MAPK kinase, is activated in response to pro-inflammatory stimuli, reactive oxygen species, and various other cellular stressors. Previous clinical studies have targeted ASK1 as a treatment for diabetic kidney disease, liver disease, or hypertension. McMaster researchers have, for the first time, identified ASK1 inhibitors (such as GS444217 and Selonsertib) as pan-antiviral inhibitors.

The novel findings demonstrate that ASK1 is required during viral replication, as it limits cytokine production such as IL6, TNF alpha, and IL8. ASKI inhibition demonstrates antiviral properties against a wide range of viruses, including SARS-CoV-2.

Applications

Universal and pan-antiviral inhibitors:

• SARS-CoV-2
• VSV
• HSV
• HIV
• Vaccinia

Benefits

Unlike bacteria, viruses are not susceptible to antibiotics. However, antiviral medications are available to limit or inhibit virus replication and ultimately reduce disease outcome. ASK1 inhibitors specifically, are shown to be universal antiviral inhibitors which target viruses from diverse viral families.