Abstract

PVI is a novel diagnostic tool developed to distinguish immune thrombocytopenia (ITP) from other thrombocytopenic disorders by quantifying fluctuations in platelet counts over time. By providing an ordinal score from 0 to 6, the PVI effectively captures the severity and variability of thrombocytopenia, offering a unique and precise measure that correlates strongly with ITP.

Applications

• Clinical Diagnosis: Assists hematologists in diagnosing ITP by identifying unique platelet count fluctuations characteristic of the disorder.
• Research Tool: Serves as a quantitative measure in clinical studies exploring the dynamics of platelet counts in thrombocytopenic patients.

Advantages

• Improved Diagnostic Accuracy: Offers high sensitivity (95.2%) and specificity (81.8%) for diagnosing definite ITP, outperforming traditional methods that do not account for platelet variability.
• Objective Measurement: Standardizes the assessment of platelet count fluctuations, providing a reliable tool for clinical and research applications.
• Easy Integration: Implemented via a web application, allowing for seamless integration into existing clinical workflows and easy access for ongoing studies and trials.