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Chemistry 23-066

Modulated membrane chromatography device

Schematic design of modulated membrane chromatography device

Tech ID



Raja Ghosh

Patent Status

US provisional filed

Stage of Research

Development stage


Tao Li
Business Development Officer


Ion exchange membrane chromatography is widely used for purification of proteins and other biomacromolecules. However, existing methods are not suitable for high-resolution purification. To address this issue, researchers at McMaster University have developed a modulated membrane chromatography device that combines a positively charged binding membrane and a negatively charged modulating membrane, which can separate biological macromolecules with high-resolution.


Separation of biological macromolecules, including carbohydrates such as dextran, lipids such as fatty acids, proteins such as enzymes and antibodies, and nucleic acids such as RNA and DNA


  • High-resolution of separation
  • Low-cost of manufacture
  • Purification of hard to separate proteins such as aggregates and variants

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