Carbonic anhydrase-catalyzed isotope equilibrium for oxygen isotope analyses of aqueous samples
US patent pending
CA patent filed
Stage of Research
Data is available upon request
Business Development and Intellectual Property
Oxygen isotope studies of aqueous samples are typically determined through the isotopic equilibration of CO2 gas and H2O.This equilibration process typically takes 24 hours in a closed undisturbed reaction vessel, limiting laboratory throughput.
The technique developed at McMaster utilizes carbonic anhydrase (CA) to rapidly catalyze the oxygen isotope exchange reaction, bringing the reaction time from 24 hours to less than one hour. This technique is compatible with commercially available CO2-H2O equilibration devices, and can be easily and immediately adopted by any laboratories that measure the oxygen isotope compositions of aqueous samples.
Oxygen Isotope analyses in fields such as:
- Environmental sciences: Geology, Hydrology
- Carbonate isotope analyses
- Reduce equilibrium reaction time from 24h to<1h.
- Increase laboratory throughput capability.
- Compatible with existing commercially available equipment.