The following technologies are available for licensing through the McMaster Industry Liaison Office (MILO):
- Chlamydia Vaccine: These novel recombinant Chlamydial proteins, alone or in combination, are suitable immunogens for a vaccine formulation to prevent Chlamydia infections in humans
- Method for Determining Coagulation Activation in Whole Blood: Measuring coagulation activation, including thrombin generation, is useful in a number of clinical conditions. McMaster researchers have developed a novel method and class of substrates to do this using whole blood, for instance from a finger prick, using conventional fluorescence equipment
- Biomarkers of CF for Better Screening and Therapeutic Treatments: A panel of CF-specific biomarkers from blood spot extracts and sweat samples for CF screening and guide discovery of new molecular targets
- Comprehensive Antibiotic Resistance Database: A bioinformatic database of resistance genes, their products and associated phenotypes. Resource for antimicrobial resistance (AMR) surveillance in healthcare, agriculture and environmental settings
- Hybrid Cell Membrane Liposomes as Carriers for Drug Delivery: A method to efficiently purify biological cell membranes and modify membranes with synthetic lipids to create hybrid liposomes with tunable membrane properties.
- Treatment of Breast Cancer: Dronedarone is an FDA-approved drug that has shown anti-cancer activity in breast cancer cell cultures, sphere forming assays and in mice
- Plant Derived Pharmacological Chaperones for Treatment of PKU: These plant-derived natural products offer a safe, yet effective, therapeutic treatment of PKU via nutritional supplementation
- Laboratory Scores for Risk Stratification of Patients with Possible Cardiac Injury: Using important biochemical parameters to accurately determine the risk of an acute cardiovascular event or death with easy interpretation
- Biomarkers for Wound Healing:This novel technique equips wound care specialists with a powerful new diagnostic tool for assessing wound healing status and predicting healing trajectory to manage problem wounds
- Sepsis Prognostic Tool to Create Personalized Mortality Risk Profiles: A predictive algorithm for assessing personalized sepsis-related mortality risk profiles of septic patients with utility for both clinical trials and patient care
- Antibiotic Resistance Platform Assay to Measure Factor Xa Inhibitors in Blood and Plasma: The antibiotic resistance platform (ARP) can be used for both the identification of antibiotic adjuvants and for antibiotic dereplication
- Assay to Measure Factor Xa Inhibitors in Blood and Plasma: This assay can test both plasma and citrated whole blood to allow for simple, on-demand usage in hospital labs
- Laboratory Score for Predicting Cardio-Toxicity: A novel algorithm to detect risk of cardio-toxicity using a combination of easily detectible cardiac biomarkers in the blood
- Omega 3 Fatty Acid Supplementation for the Attenuation of Skeletal Muscle Disuse Atrophy : Using n-3 PUFAs to slow muscle lost during periods of immobilization with no known negative physiological side effects
- Local Infusion of Immuno-Therapeutics (LIIT): A platform technology with hydrogels that can sustain and localize antibody/protein release, relevant to a wide variety of clinical applications
- Adenovirus Spray Drying: A robust method for preparing a thermally stable adenovirus formulation, extending the possible applications of adenovirus-based vectors as thermally stable vaccines
- Novel Compounds for Reversing Β-Lactam Resistance in MRSA :Novel antimicrobial compounds of new chemical class and new mode of action for therapeutics as monotherapy or in combination with other antibiotics for reversing beta-lactam resistance in MRSA.
- Rapid Fabrication of Self-Assembled Multicellular 3D Tissue Constructs :Rapid self-assembly of multicellular 3D structures in a mold allows for the formation of robust tissue constructs of various shapes with physiologically relevant cell densities and positioning.
- 3D Bioprinting and Lamination Approach to Create Complex In Vitro Biological Models: A bioprinting on scaffold approach for creating 3D tissue models to recapitulate complex biological tissues with perfusable channels for performing in vitro assays.
- Rapid, Accurate and Sensitive Molecular Systems to detect pathogenic Candida species: A rapid, efficient and low-cost nucleic acid identification tool for pathogenic Candida in human test samples with clinical relevance, increased accuracy and reliability
- Antibacterial Phage Hydrogels: A self-healing and autofluorescent hydrogel made entirely of bacteriophage can be used for a variety of medical and environmental applications
- Non-invasive Diagnosis and Treatment Monitoring of Inflammatory Bowel Disease: A reliable, low-cost method for the diagnosis of Crohn’s disease and ulcerative colitis using urinary biomarkers offering a minimally invasive strategy for early detection.
Enhancing Antimicrobial Activity Using Bicarbonate: Using bicarbonate to potentiate the activity of antibiotics and develop novel therapies.
Bicarbonate as a Modulator for Antibiotics: Using bicarbonate to modulate a microorganism’s response to an antimicrobial agent.
Serum Biomarkers for Early Detection of Peripheral Artery Disease: A novel panel of PAD-specific biomarkers from serum for the early detection of PAD in asymptomatic patients.
- Brush Amphiphilic Block Copolymers for Drug Delivery: Brush amphiphilic block copolymers for drug delivery and other biomedical applications.
- Printable Enzyme-Stabilizing Hydrogels for Biosensing and Drug Discovery: A printable in-situ hydrogel-based drug screening platform for HTS that can discriminate between true and “promiscuous” inhibitors.
- Deep Learning Model Predicting Therapeutic Potential of Chemicals: Deep learning model that predicts the mechanism of action and therapeutic utility of uncharacterized chemical compounds, relevant pharmaceutical implications for drug re-purposing.
- Gene signature for predicting progression and prognosis of adrenocortical carcinoma: Gene signature biomarker for diagnosing the progression and prognosis of adrenocortical carcinoma.
- Gene signature for predicting progression and prognosis of prostate cancer and adrenocortical carcinoma: Gene signature biomarker for diagnosing the
progression and prognosis of prostate and adrenal carcinomas.
- Gene signature for diagnosing kidney and adrenal carcinomas: Gene signature biomarker for diagnosing the progression and prognosis of kidney and adrenal carcinomas.
- Novel β-Lactamase Inhibitor: A unique inhibitor of metallo-β-lactamases that can be used to re-sensitize antibiotic resistant bacteria to β-lactam antibiotics.
- Oncolytic Virus for Cancer Therapy using Bovine Herpesvirus Type 1 (BHV-1): A new protocol to efficiently generate recombinant BHV-1.
- Thermo-Gel Polymer System for Improved Ophthalmic Drug Delivery: Schematic of thermo-responsive eyedrops for controlled degradation and sustained drug delivery.
- 3D Tissues and Assembloids Using Z-Wire Scaffolds: Scalable production and minimally invasive delivery of functional tissues and assembloids with preserved 3D anisotropic alignment and spatial organization.
- IFlowPlate: Platform Technology for Vascularizing Organoids: IFlowPlate facilitates the scalable production and testing of vascularized human stem cell derived organoids
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