Research Admin Offices:

• ROADS
• HRS

Opportunity Type:

• Grant

Value:

Up to $300,000 over two years for the Early Validation Stream & $150,000 over one year for the Early Accelerator Stream.

Disciplines:

• Faculty of Social Sciences
• Health Sciences

Sponsors:

• Ontario Institute for Cancer Research (OICR)

Deadlines:

Additional Dates:

• LOI HRS & ROADS Due Date - May 9, 2024
• LOI Sponsor Due Date - May 16, 2024
• Application Due Date (by invitation) - August 29, 2024

Description:

This opportunity supports developing Ontario’s expertise in cancer biology and drug discovery. Its aim is to create a pipeline of validated cancer targets and first-in-class or best-in-class, novel, selective lead molecules (small molecules or biologics) to attract partnerships and/or investment for further preclinical and clinical development. To generate a sustainable pipeline, CTIP will support projects that aim to provide increasing evidence of target validation and disease association using data from knowledge bases, functional assays, and drug screening in relevant in vitro and in vivo models of the cancer type of interest.

Two streams are available:

• Early Validation projects: Deliver robust translational evidence that a Target-of-Interest (TOI) is associated with a specific cancer type(s) based on data from knowledge bases and from studies demonstrating that perturbation of the TOI in relevant cell-based models produces anti-cancer effects sufficient to trigger a drug discovery campaign
• Early Accelerator projects: Deliver a validated primary assay to enable initial screening of molecules against a defined target. Preliminary evidence of linearity of results between the primary assay and supporting secondary assays under development is also required

Resources:

Additional Details.

Contact:

If applying from the Faculty of Health Sciences, unless otherwise indicated, you no longer need to send documents to HRS Intake. Your first point of contact is your assigned Senior Grants Advisor.

For more information and how to apply, contact Beatrice Flecther Senior Advisor, ROADS.